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These are direct effects on the cell populations responsible for building new bone
Ideally, the targeted receptor- or carrier-mediated transport processes for brain targeting should occur exclusively at the BBB to avoid off-target delivery
Through these mechanisms, HSP70 and HSP90 reduce the formation of neurofibrillary tangles, thereby mitigating one of the core pathological processes underlying tau-mediated neurodegeneration
Evidence suggests that OS is a common signature in neurodegenerative diseases such as Alzheimers disease (AD) [47,48,49], Huntingtons disease (HD) [50,51,52], Parkinsons disease (PD) [53,54,55] and, in particular, it is part of the tightly connected and multi-factorial set of mechanisms involved in the pathogenesis and progression of Amyotrophic lateral sclerosis (ALS) [25, 56,57,58]
humidity, 50 10%) under a 12 h12 h lightdark cycle (light, 01:00 to 13:00) with ad libitum access to chow diet (Brogaarden, Altromin, 1324) and tap water
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